A high-performance, zero-overhead, extensible Python compiler using LLVM.
Codon is a high-performance Python compiler that compiles Python code to native machine code without any runtime overhead. Typical speedups over Python are on the order of 10-100x or more, on a single thread. Codon's performance is typically on par with (and sometimes better than) that of C/C++. Unlike Python, Codon supports native multithreading, which can lead to speedups many times higher still. Codon grew out of the Seq project.
Pyston is an open source Python implementation that aims to be both highly compatible and high-performance. It uses modern JIT techniques on top of LLVM, and natively supports many CPython C extension modules via a recompile.